WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:PPAR signaling pathway       ID:03320
C=70; O=8; E=0.21; R=37.62; rawP=4.70e-11; adjP=1.17e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000132170 NA PPARG peroxisome proliferator-activated receptor gamma 5468 ENSG00000132170
2  ENSG00000124253 NA PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 5105 ENSG00000124253
3  ENSG00000099194 NA SCD stearoyl-CoA desaturase (delta-9-desaturase) 6319 ENSG00000099194
4  ENSG00000109424 NA UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 7350 ENSG00000109424
5  ENSG00000181092 NA ADIPOQ adiponectin, C1Q and collagen domain containing 9370 ENSG00000181092
6  ENSG00000118137 NA APOA1 apolipoprotein A-I 335 ENSG00000118137
7  ENSG00000166819 NA PLIN1 perilipin 1 5346 ENSG00000166819
8  ENSG00000170323 NA FABP4 fatty acid binding protein 4, adipocyte 2167 ENSG00000170323


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=6; E=0.42; R=14.31; rawP=4.33e-06; adjP=5.41e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000142949 NA PTPRF protein tyrosine phosphatase, receptor type, F 5792 ENSG00000142949
2  ENSG00000100504 NA PYGL phosphorylase, glycogen, liver 5836 ENSG00000100504
3  ENSG00000079435 NA LIPE lipase, hormone-sensitive 3991 ENSG00000079435
4  ENSG00000005249 NA PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 5577 ENSG00000005249
5  ENSG00000169710 NA FASN fatty acid synthase 2194 ENSG00000169710
6  ENSG00000124253 NA PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 5105 ENSG00000124253


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=6; E=0.99; R=6.06; rawP=0.0005; adjP=0.0042
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000172037 NA LAMB2 laminin, beta 2 (laminin S) 3913 ENSG00000172037
2  ENSG00000076242 NA MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 4292 ENSG00000076242
3  ENSG00000070193 NA FGF10 fibroblast growth factor 10 2255 ENSG00000070193
4  ENSG00000132170 NA PPARG peroxisome proliferator-activated receptor gamma 5468 ENSG00000132170
5  ENSG00000100311 NA PDGFB platelet-derived growth factor beta polypeptide 5155 ENSG00000100311
6  ENSG00000187098 NA MITF microphthalmia-associated transcription factor 4286 ENSG00000187098


Database:KEGG pathway       Name:Melanoma       ID:05218
C=71; O=3; E=0.22; R=13.91; rawP=0.0013; adjP=0.0063
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000070193 NA FGF10 fibroblast growth factor 10 2255 ENSG00000070193
2  ENSG00000100311 NA PDGFB platelet-derived growth factor beta polypeptide 5155 ENSG00000100311
3  ENSG00000187098 NA MITF microphthalmia-associated transcription factor 4286 ENSG00000187098


Database:KEGG pathway       Name:Neuroactive ligand-receptor interaction       ID:04080
C=272; O=5; E=0.83; R=6.05; rawP=0.0015; adjP=0.0063
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000151090 NA THRB thyroid hormone receptor, beta 7068 ENSG00000151090
2  ENSG00000174697 NA LEP leptin 3952 ENSG00000174697
3  ENSG00000065325 NA GLP2R glucagon-like peptide 2 receptor 9340 ENSG00000065325
4  ENSG00000050628 NA PTGER3 prostaglandin E receptor 3 (subtype EP3) 5733 ENSG00000050628
5  ENSG00000168398 NA BDKRB2 bradykinin receptor B2 624 ENSG00000168398


Database:KEGG pathway       Name:Adipocytokine signaling pathway       ID:04920
C=68; O=3; E=0.21; R=14.52; rawP=0.0012; adjP=0.0063
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174697 NA LEP leptin 3952 ENSG00000174697
2  ENSG00000181092 NA ADIPOQ adiponectin, C1Q and collagen domain containing 9370 ENSG00000181092
3  ENSG00000124253 NA PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 5105 ENSG00000124253


Database:KEGG pathway       Name:Biosynthesis of unsaturated fatty acids       ID:01040
C=21; O=2; E=0.06; R=31.35; rawP=0.0019; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000099194 NA SCD stearoyl-CoA desaturase (delta-9-desaturase) 6319 ENSG00000099194
2  ENSG00000206527 NA PTPLB protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b 201562 ENSG00000206527


Database:KEGG pathway       Name:Vitamin digestion and absorption       ID:04977
C=24; O=2; E=0.07; R=27.43; rawP=0.0024; adjP=0.0075
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000135917 NA SLC19A3 solute carrier family 19, member 3 80704 ENSG00000135917
2  ENSG00000118137 NA APOA1 apolipoprotein A-I 335 ENSG00000118137


Database:KEGG pathway       Name:Citrate cycle (TCA cycle)       ID:00020
C=30; O=2; E=0.09; R=21.95; rawP=0.0038; adjP=0.0105
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000138413 NA IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 3417 ENSG00000138413
2  ENSG00000124253 NA PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 5105 ENSG00000124253


Database:KEGG pathway       Name:Regulation of actin cytoskeleton       ID:04810
C=213; O=4; E=0.65; R=6.18; rawP=0.0042; adjP=0.0105
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000144668 NA ITGA9 integrin, alpha 9 3680 ENSG00000144668
2  ENSG00000070193 NA FGF10 fibroblast growth factor 10 2255 ENSG00000070193
3  ENSG00000100311 NA PDGFB platelet-derived growth factor beta polypeptide 5155 ENSG00000100311
4  ENSG00000168398 NA BDKRB2 bradykinin receptor B2 624 ENSG00000168398




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).